Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
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چکیده
منابع مشابه
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
INTRODUCTION Interneuronal propagation of α-synuclein has been demonstrated in a variety of experimental models and may be involved in disease progression during the course of human synucleinopathies. The aim of this study was to assess the role that neuronal injury or, vice versa, cell integrity could have in facilitating interneuronal α-synuclein transfer and consequent protein spreading in a...
متن کاملNeuron-to-neuron transmission of α-synuclein fibrils through axonal transport.
OBJECTIVE The lesions of Parkinson disease spread through the brain in a characteristic pattern that corresponds to axonal projections. Previous observations suggest that misfolded α-synuclein could behave as a prion, moving from neuron to neuron and causing endogenous α-synuclein to misfold. Here, we characterized and quantified the axonal transport of α-synuclein fibrils and showed that fibri...
متن کاملCorrection for ‘‘Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein,’’ by
Correction for ‘‘Restoring a maize root signal that attracts insect-killing nematodes to control a major pest,’’ by Jörg Degenhardt, Ivan Hiltpold, Tobias G. Köllner, Monika Frey, Alfons Gierl, Jonathan Gershenzon, Bruce E. Hibbard, Mark R. Ellersieck, and Ted C. J. Turlings, which appeared in issue 32, August 11, 2009, of Proc Natl Acad Sci USA (106:13213–13218; first published August 3, 2009;...
متن کاملRAPID COMMUNICATION Neuron-to-Neuron Transmission of a-Synuclein Fibrils Through Axonal Transport
Objective: The lesions of Parkinson disease spread through the brain in a characteristic pattern that corresponds to axonal projections. Previous observations suggest that misfolded a-synuclein could behave as a prion, moving from neuron to neuron and causing endogenous a-synuclein to misfold. Here, we characterized and quantified the axonal transport of a-synuclein fibrils and showed that fibr...
متن کاملExogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Here, we demonstrate that preformed fibrils generated from full-length and truncated recombinant α-syn enter primary neurons, probably by adsorptive-mediated endocytosis, and promote recruitment of soluble e...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-07383-6